Alkali-reduced bioactive glasses

Bioactive glasses (BGs) are promising bone substitute materials.

SEM surface morphology analysis of silicon oxycarbide samples after seven days SBF test: (a) SiCa0-T, (b) SiCa5-T, (c) SiCa12-T, and (d) SiCa50-T. The hydroxyapatite precipitation is marked in white circles for SiCa12-T.
Picture: Materials 2019, 12(23), 3862
SEM surface morphology analysis of silicon oxycarbide samples after seven days SBF test: (a) SiCa0-T, (b) SiCa5-T, (c) SiCa12-T, and (d) SiCa50-T. The hydroxyapatite precipitation is marked in white circles for SiCa12-T.

However, under certain circumstances BGs such as the well-known 45S5 Bioglass® (composition in wt%: 45.0 SiO2, 24.5 Na2O, 24.5 CaO, 6.0 P2O5) act cytotoxic due to a strong increase in pH caused by a burst release of sodium ions. Thus, the development of new bioactive glasses with low- or free- alkali content is a key part of our work. Our focus is the fundamental understanding of composition-structure-property relationship of these new materials aiming to tailor new compositions for bone tissue engineering .

  • Bioactive Silicon Oxycarbide Based Glasses & Glass-ceramics
  • Alkali reduced bioactive glasses prepared by sol-gel
  • Injectable biocomposites

[1] I. Gonzalo-Juan, R. Detsch, S. Mathur, E. Ionescu, A.R. Boccaccini, R. Riedel, Synthesis and In Vitro Activity Assessment of Novel Silicon Oxycarbide-Based Bioactive Glasses, Materials 9(12) (2016).

[2] I. Gonzalo-Juan, D.U. Tulyaganov, C. Balan, R. Linser, J.M.F. Ferreira, R. Riedel, E. Ionescu, Tailoring the viscoelastic properties of injectable biocomposites: A spectroscopic assessment of the interactions between organic carriers and bioactive glass particles, Materials & Design 97 (2016) 45-50.

[3] F.T. Xie, I. Gonzalo-Juan, H. Breitzke, C. Fasel, M. Trapp, G. Buntkowsky, H.J. Kleebe, R. Riedel, A.R. Boccaccini, E. Ionescu, Effect of Ca and B incorporation into silicon oxycarbide on its microstructure and phase composition, Journal of the American Ceramic Society 102(12) (2019) 7645-7655.

[4] F.T. Xie, E. Ionescu, M. Arango-Ospina, R. Riedel, A.R. Boccaccini, I. Gonzalo-Juan, Facile Preparative Access to Bioactive Silicon Oxycarbides with Tunable Porosity, Materials 12(23) (2019).

[5] S.I. Schmitz, B. Widholz, C. Essers, M. Becker, D.U. Tulyaganov, A. Moghaddam, I. Gonzalo de Juan, F. Westhauser, Superior biocompatibility and comparable osteoinductive properties: Sodium-reduced fluoride-containing bioactive glass belonging to the CaO–MgO–SiO2 system as a promising alternative to 45S5 bioactive glass, Bioactive Materials 5(1) (2020) 55-65.